Premier League Predictions Gameweek 2: Arsenal, Liverpool to maintain winning starts

We’ve got picks for matches including Man City, Arsenal and Liverpool, with plenty of goals on the horizon.

Premier League Predictions Gameweek 2

Odds via Sky Bet, correct at the time of publishing and subject to change.

West Ham vs Chelsea Prediction: Blues to win London battle

• Date: 22/08/2025
• Kick-off time: 9 pm
• Our tip: Chelsea to win @ 4/6 with Sky Bet

Gameweek 1 didn’t quite go as planned for Enzo Maresca’s men as they struggled to find a way past Crystal Palace. The Eagles have had a good few months, but the Blues were still expected to beat them - especially on home soil. Their inability to do so proved frustrating. 

Next up, however, they face a struggling West Ham United side. The Hammers suffered a 3-0 defeat to newcomers Sunderland over the weekend, and Chelsea have more firepower than the Black Cats. This London clash should go the way of the visitors, but they’ll need to improve.

Man City vs Tottenham Prediction: Spurs’ struggles to continue

• Date: 23/08/2025
• Kick-off time: 1.30 pm
• Our tip:Man City to win @ 4/9 with Sky Bet

Tottenham Hotspur got back to winning ways on the opening day of the season, but it was against Burnley. It’s safe to say they’ll face a more difficult challenge when they go up against Pep Guardiola’s Manchester City. It’s tough at the best of times, let alone away at the Etihad.

City had an even better first game than Spurs, as they thumped Wolverhampton Wanderers 4-0, and Erling Haaland is back on the scoresheet. That’ll be a concern for a Tottenham side who are still in transition, so it’s no surprise to see Guardiola’s side as favourites. The hosts should come out on top.

Arsenal vs Leeds Prediction: Gunners must improve

• Date: 23/08/2025
• Kick-off time: 6.30 pm
• Our tip: Arsenal to win @ 1/4 with Sky Bet

Both teams secured narrow wins on the opening day and now lock horns in London. Arsenal managed to beat Manchester United despite not being at their best, while Leeds United saw off Everton. The Premier League newbies face a far sterner challenge at the Emirates, however, and they could struggle. 

Mikel Arteta’s Gunners were far from convincing at Old Trafford, and they will need to improve a lot if they’re to challenge this season. Yet, they should still have too much for Daniel Farke and his team. Viktor Gyokeres will likely see this one as a big chance to get off the mark for his new club.

Fulham vs Man Utd Prediction: Red Devils backed for first win

• Date: 24/08/2025
• Kick-off time: 5.30 pm
• Our tip: Man Utd to win @ 5/4 with Sky Bet

Fulham showed resilience against Brighton & Hove Albion on Matchday 1, and they’ll be confident with the advantage of playing at home. However, despite losing, Manchester United could take a lot of positives from defeat to Arsenal and see signs of progress. Matheus Cunha, for example, appears to be a strong signing.

The Cottagers have been solid under Marco Silva, so a high-scoring affair is unlikely. However, the Red Devils could still come out on top. There might also be a first start for Benjamin Šeško, and anyone who’s seen him knows how much trouble he can cause. We’re backing an away win.

Newcastle vs Liverpool Prediction: Isak subplot spices up the clash 

• Date: 25/08/2025
• Kick-off time: 9 pm
• Our tip: Liverpool to win @ 1/1 with Sky Bet

Much of the build-up to this fixture will surround Alexander Isak, and - at this point - it’s unlikely he’ll even play. The Swede’s future is up in the air, and this offers an extra bit of spice to this affair. Aston Villa were unable to find the net without him - even up against 10 men for the final half an hour.

Liverpool were inconsistent against Bournemouth. This could hint at what’s to come, with Arne Slot’s top-heavy Reds simply able to outscore their opponents. We could see goals at both ends here, but the visitors are expected to take home the three points.