Bournemouth midfielder Jack Wilshere's match lasted just 45 minutes on Monday as he was forced off with an apparent ankle injury against Manchester City.
The Arsenal loanee, 25, appeared to hurt his ankle when challenging David Silva for the ball not long before half-time.
Injured Gabriel Jesus subbed for Aguero
Wilshere couldn't make it until the break and was withdrawn in first half stoppage time for forward Benik Afobe, with Bournemouth chasing a 1-0 deficit against Pep Guardiola's visitors.
Afobe's arrival is expected to see Eddie Howe's men - who trail through a Raheem Sterling strike - shift into a 4-4-2 formation in the second half.
Wilshere was the third player to be withdrawn in an injury-strewn first half, with team-mate Simon Francis lasting just 23 minutes before being replaced by Tyrone Mings.
Previously, Manchester City forward Gabriel Jesus didn't even make it until the 15-minute mark having taken an unpleasant knock to the ankle, and Sergio Aguero was brought on for him.