Second-placed Feyenoord travel to third-placed NEC on Sunday. Kick-off is set for 14:30 and the match will be broadcast live on ESPN 1.
Anel Ahmedhodzic, Luciano Valente and Anis Hadj Moussa are ruled out due to fitness concerns, leaving Van Persie with difficult selection headaches.
Timon Wellenreuther will start in goal, while Mats Deijl, Tsuyoshi Watanabe, Thijs Kraaijeveld and Jordan Bos make up the defence in this Vriendenloterij Eredivisie showdown.
Tobias van den Elshout, who recently extended his contract at De Kuip, will make his first-team debut, while Jakub Moder and Oussama Targhalline complete the midfield. In-beom Hwang and Sem Steijn remain sidelined through injury.
Gonçalo Borges steps in for the still-sidelined Hadj Moussa, while Raheem Sterling occupies the left flank and Eredivisie top scorer Ayase Ueda leads the attack in Nijmegen.
Feyenoord are now just one point clear of NEC, who are chasing a Champions League spot. Earlier this season, the Rotterdammers suffered a 2-4 defeat to Sunday’s hosts in a thrilling De Kuip encounter.
Probable Feyenoord line-up: Wellenreuther; Deijl, Watanabe, Kraaijeveld, Bos; Targhalline, Moder, Van den Elshout; Borges, Ueda, Sterling.