Dominic Solanke makes his first Premier League start for Liverpool with Mohamed Salah held in reserve at Stoke City on Wednesday night.
The Under-20 World Cup Golden Ball winner will operate with Sadio Mane and Roberto Firmino, both restored to the line-up after being on the bench against Chelsea, in the front three.
Emre Can, marking his 100th league appearance for the Reds, has shaken off a knock to line up in midfield with captain Jordan Henderson rested and on the bench.
Gini Wijnaldum replaces James Milner in the centre, with Alex Oxlade-Chamberlain partnering him as Philippe Coutinho is rotated out.
Dejan Lovren returns to the heart of defence after sitting out the last two games through injury.
Liverpool starting XI: Mignolet, Gomez, Matip, Lovren, Moreno, Can, Wijnaldum, Oxlade-Chamberlain, Mane, Firmino, Solanke. Subs: Karius, Alexander-Arnold, Milner, Henderson, Coutinho, Salah, Sturridge.
Stoke City starting XI: Grant, Zouma, Shawcross, Martins Indi, Diouf, Fletcher, Allen, Pieters, Shaqiri, Crouch, Choupo-Moting. Subs: Haugaard, Wimmer, Adam, Afellay, Ramadan, Jese, Berahino.