Already through to the next round and with their slim chances of topping the group resting on Young Boys pulling off a shock win over Juventus, the Red Devils are unlikely to focus too much attention on this game ahead of the weekend.
Nevertheless, they are available at 9/5 (2.80) with William Hill to secure a morale-boosting victory at the Estadio de Mestalla.
Marcelino's men definitely have nothing to play for as they sit marooned in third place, but are priced at 31/20 (2.55) to leave the competition on a high by coming out on top.
The sides shared a 0-0 draw in the reverse encounter at Old Trafford, and you can get odds of 23/10 (3.30) on them cancelling each other out once again.
Jose Gaya is suspended for the hosts, while Gabriel Paulista is ruled out through injury after being forced off in Saturday's 1-1 draw with Sevilla.
Paul Pogba is set to be recalled in a rotated visiting line-up with Victor Lindelof, Alexis Sanchez, Matteo Darmian, Eric Bailly, Chris Smalling and Anthony Martial all injured or doubtful.
Fans who found the last meeting between this pair an uninspiring spectacle would do well to avoid Wednesday's rematch, where entertainment is likely to be at least as thin on the ground.
Los Che have no motivation to attack, although a defensive record that has seen them concede only nine times in 11 home matches this season should at least prevent Jose Mourinho's men adding too heavily to the return of three goals in the last four Champions League games.
Indeed, the smart money is surely on the 8/11 (1.73) price for under 2.5 goals to be scored for Valencia's 10th home match in 12, as well as a fourth Champions League match in five for a distracted United.