Despite that defeat to the Red Devils, Switzerland can still make the play-offs of the UEFA Nations League with a two goal, 1-0 or 2-1 win on Sunday, while Roberto Martinez's side will be through with a draw.
Switzerland have not lost a competitive match on home soil for over four years and William Hill price them at 7/2 (4.50) to claim a victory.
Belgium have won the only two meetings between these sides this century, winning 2-1 last month in the Nations League and recording a friendly win by the same scoreline in 2016. The Red Devils can be backed at 11/10 (2.10) with the draw priced at 12/5 (3.40).
Belgium have a number of injury issues with centre-backs Thomas Vermaelen and Jan Vertonghen both missing. Also absent are Kevin De Bruyne and Mousa Demeble, with Romelu Lukaku also unlikely to feature.
Switzerland are missing Arsenal full-back Stephan Lichtsteiner, who has pulled out of the squad through injury.
If Switzerland struggled against the side ranked 96th in the world, then logic would dictate they could have some troubles against the team currently top of the rankings.
Belgium's firepower is well documented and the team that finished third at the World Cup have scored over 1.5 goals in 11 of their last 14 matches in all competitions.
They will fancy their chances of getting among the goals against a Swiss side who have kept just a solitary clean sheet in their last nine matches.
Tips and predictions
Belgium are priced at a healthy looking 6/5 (2.20) to score at least two goals in the game and that looks like an excellent option, given their strong scoring record.