Sevilla bid farewell to the Champions League on Wednesday evening and the Andalusians' current position in La Liga means they will not be returning to the competition any time soon.
Vincenzo Montella's side sit seventh in the table, 18 points off fourth, with a more realistic target being overtaking their opponents on Saturday afternoon.
Villarreal have been deeply inconsistent this term although they are still on course to secure European football for next season and are sat in sixth place.
Latest odds
bet365 offer a home win at 17/20 (1.85), with Villarreal priced at 10/3 (4.33) and the draw available at 13/5 (3.60).
AFP
Watch and bet live on Sevilla v Villarreal
bet365 customers in the UK can watch and bet live on this fixture. Your account must be funded or active (have a bet placed in the previous 24 hours) to enjoy the action.
Team news
Simon Kjaer will be missing for Sevilla, with the Danish defender facing a race against time to be fit for next weekend's Copa del Rey final.
For Villarreal, Pablo Fornals has been given the all-clear after fainting during last weekend's game against Athletic Bilbao, although it remains to be seen if he goes straight back into the team.
Low-key start at the Sanchez Pizjuan
Saturday's game is the early kick off in La Liga and given Sevilla's exertions on Wednesday night in Munich, there is every chance they might be a little sluggish.
Montella's men also had a draining match last weekend against Barcelona, and there is little likelihood of them making a high-tempo start.
Villarreal, for their part, have also failed to score a first half goal in any of their last six games, so opposing goals early on makes plenty of sense.
Tips and predictions
Backing no goal to be scored before 27 minutes at 5/6 (1.83) looks to be a tempting option, given the expected slow start. For higher odds, backing a goalless opening half at 9/4 (3.25) could also appeal.
Prices correct at time of writing. Please gamble responsibly.
No goal before 27 minutes at 5/6 (1.83) with bet365 for a 2.5pt stake