The Tartan Army face an uphill battle to qualify after losing two of their first four Group I fixtures, leaving them three points adrift of their second-placed guests.
Scotland vs Russia latest odds
Having lost just one of their last 14 competitive home matches, they are available at 19/10 (2.90) with bet365 to give their qualification chances a major boost with a crucial win in Glasgow.
However, Stanislav Cherchesov's men have won their last three group games by a combined scoreline of 14-0, and are 7/4 (2.75) favourites to deal their hosts a major blow by coming out on top here.
This pair shared two draws when they last met in qualification for Euro 96, and you can get odds of 9/5 (2.80) on them cancelling each other out once again.
Scotland vs Russia team news
Grant Hanley and Liam Palmer have withdrawn from the Scotland squad through injury, with David Bates and Mikey Devlin drafted in as replacements.
Ruslan Kambolov has been called in to replace Anton Miranchuk, who is unavailable after injuring his thigh in Lokomotiv Moscow's 2-1 win over Rostov.
Scotland vs Russia preview
Having kept just four clean sheets in 16 fixtures and opened this campaign with a chastening 3-0 defeat against Kazakhstan, Steve Clarke’s men may struggle to contain an attack that has scored more goals than any other team in qualification so far.
However, they may have more joy at the other end of the pitch, having found the net in 13 of the last 14 competitive matches in front of their own fans.
Scotland vs Russia predictions
With Scotland needing to push forward in search of victory, odds of 6/4 (2.50) seem very generous on over 2.5 goals being scored for their eighth game in nine – and a fifth in seven for Russia.
All odds correct at time of publish. Please gamble responsibly.