Beaten in Paris in midweek, the Reds will look to bounce back at Anfield on Sunday when they welcome their oldest rivals.
Everton have not won a derby since 2010, and have not tasted victory on enemy soil since 1999, but Marco Silva's side will arrive into this meeting buoyed by recent results. The Blues sit sixth in the Premier League table, and will be seeking to inflict a first league defeat of the season on their neighbours.
Here, Goal takes a look at everything you need to know ahead of Sunday's game...
Jurgen Klopp will assess his troops after the midweek loss to PSG, a disappointing night for his side which leaves their Champions League hopes hanging by a thread.
A number of players missed that game due to injury and illness. Adam Lallana was due back in training on Thursday and could be in contention for a place on the bench, while Divock Origi, Dominic Solanke and Nathaniel Clyne will all be monitored.
Liverpool will be without captain Jordan Henderson, who will serve a one-match ban having been sent off at Watford last weekend.
Likely Liverpool Starting Line-Up
Decisions, decisions, decisions, for Klopp.
The expectation will be that Liverpool will return to their 4-2-3-1 system for this game, with Xherdan Shaqiri likely to earn a recall, either as a No.10 or on the right of the attack. If it is the latter, then Mohamed Salah will start as the No.9 with Roberto Firmino behind.
Trent Alexander-Arnold should earn a recall at right-back, with Joe Gomez taking Dejan Lovren's place at centre-back. Then the big question is the midfield, which looked so powderpuff in Paris. Henderson's absence means Gini Wijnaldum is a certainty to start, but will it be James Milner, Fabinho or Naby Keita alongside him. The smart money is on Milner, the vice-captain, though many would rather see a change of approach from Klopp with one or both of his new-boys starting.
Everton Team News
The Blues have no major doubts, with Silva boasting a virtually fully-fit squad.
He chould choose up to six derby debutants, with Yerry Mina, Kurt Zouma, Lucas Digne, Bernard, Andre Gomes and Richarlison all hoping to feature.
TV Channel & Kick-Off Time
The fixture will be broadcast live in the UK on Sky Sports Main Event and Sky Sports PL, kick off 4.15pm UK time. Highlights can be found on Match of the Day 2 on BBC One, 10.30pm Sunday.
In the United States the game can be watched live on television on NBC Sports, kick-off 11.15am ET.
Best Opta Match Facts
This is the 232nd meeting between Liverpool and Everton in all competitions – the Reds are unbeaten in each of their last 17 matches against the Toffees (W8 D9).
Everton are winless in 18 Premier League trips to Anfield against Liverpool (D9 L9) since a 1-0 win in September 1999.
This will be the 100th top-flight Merseyside derby played at Anfield – Liverpool have won 43 to Everton’s 23, with 33 draws.
Liverpool’s current run of 17 matches without defeat against Everton in all competitions is their longest ever unbeaten run against their rivals.
Although there have been more red cards awarded in this fixture than any other in Premier League history (21), there have only been two awarded in the last 16 meetings, both to Everton; Liverpool haven’t received a red card in this fixture since February 2010.
Liverpool remain unbeaten in the Premier League this season (W10 D3), while their record of just five goals conceded is their fewest at this stage of any of their 115 English league campaigns.
Everton have won just one of their last 51 Premier League away games against the other five ever-present sides in the competition (D18 L32), beating Man Utd 1-0 in December 2013.
Liverpool have kept a clean sheet in 10 of their last 11 Premier League home games, conceding only against the league’s lowest away scorers this season (Cardiff).
Marco Silva is looking to become the first Everton manager since Joe Royle in November 1994 to win his first Merseyside derby in the Premier League; no Everton manager has ever won their first league match against Liverpool at Anfield, stretching back to their first meeting in November 1894.
Liverpool boss Jurgen Klopp has never beaten Everton’s Marco Silva in the Premier League in two previous meetings (W0 D1 L1) – Silva remains the only manager the German has faced more than once without winning in the competition.
Among current Premier League players, only Harry Kane (7) has scored more Premier League goals against Everton than Liverpool’s Daniel Sturridge (6).
Mohamed Salah could make his 50th Premier League appearance for Liverpool in this game. He’s scored 39 goals for the Reds – only two players have ever scored more in their first 50 for a club in the competition (Alan Shearer 41 for Blackburn and Andy Cole 41 for Newcastle).