While any title aspirations have long since ended, Atletico Madrid still have plenty to play for as Los Rojiblancos look to seal third place in La Liga and secure automatic qualification to the Champions League.
Sevilla are just three points behind Diego Simeone's men, meaning Atleti cannot allow themselves to be distratced by their forthcoming Madrid derby in the Champions League semi-final. Villarreal meanwhile head to the Vicente Calderon with a Europa League spot almost guaranteed, the only real doubt being whether Fran Escriba's men will finish fifth or sixth.
Back in December, the Yellow Submarine inflicted one of the heaviest defeats of the season on Atletico with a 3-0 win at the Estadio de la Ceramica, althoughLos Rojiblancos have greatly improved and look considerably more solid since then.
bet365, who are live streaming this match for UK-based customers, as ever offer a home win at 4/9 (1.44) while the visitors to the Spanish capital are offered at 17/2 (8.50) and the draw can be backed at 16/5 (4.20).
Over the last few years, there is a selection in this fixture which has paid out with great regularity and that is opposing both teams to score. This bet has proved profitable in each of the last six meetings, and a repeat is offered at 61/100 (1.61).
With La Liga's two best defences meeting, it is logical to think this will be a low-scoring encounter and under 2.5 goals is offered at 3/4 (1.75). For more appealing odds, we will combine the two aforementioned selections with both teams to score 'no' and under 2.5 goals offered at an extremely healthy looking 11/10 (2.10).
This bet has paid out in seven of the last nine meetings between these two sides and seems to have an excellent chance of doing so once more on Tuesday evening.