Cardoso's knock is a blow for a U.S. side that has otherwise used the last few months to return to full fitness. Antonee Robinson, after struggling with knee and muscle injuries, is now playing regularly for Fulham.
Meanwhile, Sergino Dest made his long-anticipated return for PSV last week after a couple of months out with a hamstring issue. Pochettino will hope he can pick from a mostly fit squad ahead of a home World Cup.