Maguire was distraught after the news and took to Instagram to express his disappointment.
"I am devastated not to have been selected to play for England at the Euros this summer," he wrote.
"Despite my best efforts, I have not been able to overcome an injury to my calf. Maybe I pushed myself too hard, to try and make it. Simply, I am absolutely gutted. For me, representing England is the highest honour. It means everything to me. If I can’t help the team as a player, I will support them as a fan – along with the rest of the country. Go and win it boys.
"Next, I will return to the supervision of the Manchester United medical team in order to prepare for next season."