Louisville's first game at home promises to be a far sterner challenge than last week’s scoreline might imply.
The Cardinals return to action fresh off a commanding 51-17 win over Eastern Kentucky, while James Madison rolls in with plenty of momentum after dismantling Weber State 45-10.
The Dukes make the trip to Louisville with the underdog tag, but they bring confidence, a punishing ground game, and a defense that prides itself on discipline. With postseason ambitions alive in Harrisonburg and ACC credibility up for grabs, this early-season showdown could set the tone for how high either program can climb.
Here, GOAL brings you everything you need to know about how to watch the Louisville vs James Madison NCAAF game, plus plenty more.
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Louisville vs James Madison: Date and kick-off time
Louisville will take on James Madison in a highly anticipated NCAAF game on Friday, September 5, 2025, at 7:00 pm ET or 4:00 pm PT at L&N Credit Union Stadium in Louisville, Kentucky.
| Date | Friday, September 5, 2025 |
| kick-off Time | 7:00 pm ET or 4:00 pm PT |
| Venue | L&N Credit Union Stadium |
| Location | Louisville, Kentucky |
How to watch Louisville vs James Madison on TV & stream live online
- TV channel: ESPN2
- Streaming service: Fubo
Streaming the game with a VPN
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Louisville vs James Madison team news & key players
Louisville Cardinals team news
Against Eastern Kentucky, Miller Moss steered Louisville's attack with 223 passing yards on 17-of-25 completions (68%), tossing one touchdown alongside two picks. He chipped in a rushing score as well. Isaac Brown exploded on the ground, turning just six carries into 126 yards — an eye-popping 21 yards per attempt — with two touchdowns. Out wide, Chris Bell was the go-to target, hauling in five catches for 63 yards.
James Madison Dukes team news
For James Madison, Alonza Barnett III impressed by going 14-for-22 with 130 yards and a touchdown through the air, adding 30 yards and a score on the ground. George Pettaway showcased his burst with 99 rushing yards on only 10 carries, while Michael Scott contributed four catches for 38 yards in a reliable showing.