How to watch San Diego Padres vs Cleveland Guardians MLB game: Live stream, regional networks, team news and start time

The Cleveland Guardians and San Diego Padres wrap up their three-game interleague set on Wednesday at Petco Park, with the Guardians hoping to snap out of their offensive slump against a red-hot Padres squad.

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Cleveland's bats have gone ice-cold, producing just two runs across the first two games of the series. Tuesday’s performance was particularly frustrating, as the Guardians managed only two hits—matching their total errors. Logan Allen struggled on the mound, lasting 5.1 innings while allowing four earned runs on seven hits and issuing five walks. Cleveland's early-season trend has been clear: when the offense clicks, they win, but when it falters, they can’t find a way to manufacture runs.

San Diego has wasted no time asserting itself as an early-season powerhouse, rolling to a perfect 6-0 start. The pitching staff has been lights-out, allowing just five total runs over their last five games. Tuesday's 7-0 victory showcased that dominance, with Michael King delivering a masterful outing—five shutout innings, two hits allowed, and an eye-popping 11 strikeouts. Fernando Tatis Jr. didn’t record a hit but still found ways to contribute, scoring a run and driving in two with a pair of walks.

Here, GOAL brings you everything you need to know about how to watch the San Diego Padres vs. the Cleveland Guardians MLB game, plus plenty more.

How to watch San Diego Padres vs Cleveland Guardians MLB game on TV & stream live online

• Local TV Channel: SDPA and CLEG
• Streaming service: Fubo

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To watch the entire MLB season, Fubo and DirecTV Stream are the two best streaming services for baseball fans. Both carry MLB.tv for out-of-market access to games and you can also check out our table below for information on regional sports networks and where to find them.

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San Diego Padres vs Cleveland Guardians: Date and First-Pitch time

The Padres will take on the Guardians in an electrifying MLB game on Wednesday, April 2, 2025, at 4:10 pm ET/1:10 pm PT at PETCO Park in San Diego, California.

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San Diego Padres vs Cleveland Guardians team news, injury reports & key players

San Diego Padres team news

Manny Machado anchored the Padres' lineup last season, slashing .275 with 29 home runs and 105 RBI. Jackson Merrill impressed with a .292 average, a .326 OBP, and a .500 slugging percentage, while Luis Arraez hit .314 with four homers and 46 RBI. Jake Cronenworth posted a .241 average with a .324 OBP and a .390 slugging percentage.

The Padres counter with Dylan Cease, who is searching for a sharper performance after a shaky first start. The righty gave up three runs on four hits in 4.1 innings against Atlanta, making him one of the few San Diego arms yet to hit top form.

Cleveland Guardians team news

On the Guardians’ side, José Ramírez put up big numbers last season, launching 39 home runs and driving in 118 runs. Steven Kwan hit .292 with 140 hits, while Carlos Santana contributed 23 home runs and 26 doubles. Lane Thomas batted .237 with 26 doubles, three triples, and 15 home runs.

The Guardians will send Ben Lively to the hill, looking for a more efficient outing than his season debut. The right-hander owns a 5.40 ERA after allowing three runs on four hits in five innings against Kansas City.

San Diego Padres vs Cleveland Guardians head-to-head record