The Los Angeles Chargers (2-1) head north to Levi’s Stadium to square off with the San Francisco 49ers (1-1) on Aug. 23, with kickoff slated for 8:30 p.m. ET in Santa Clara.
The Chargers slipped to 2-1 in preseason play after a nail-biting 23-22 loss to the Rams, while the Niners are coming off a humbling 30-9 defeat to the Broncos earlier this month.
READ MORE: Fubo Review: Pricing, plans, subscriptions, free trials and more
San Francisco 49ers vs Los Angeles Chargers: Date and kick-off time
49ers will take on Chargers in a highly anticipated NFL game onSaturday, August 23, 2025 at 8:30 pm ET or 5:30 pm PT, at Levi’s Stadium in Santa Clara, CA, United States.
| Date | Saturday, August 23, 2025 |
| Kick-off Time | 8:30 pm ET or 5:30 pm PT |
| Venue | Levi’s Stadium |
| Location | Santa Clara, CA |
How to watch San Francisco 49ers vs Los Angeles Chargers on TV & stream live online
Local TV Channel: KCBS (CBS/2 - Los Angeles), KPIX (CBS/5 - San Francisco)
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San Francisco 49ers vs Los Angeles Chargers team news
San Francisco 49ers team news
For San Francisco, Mac Jones drew the start against Denver, completing 4-of-7 throws for 74 yards but also tossing a pick. Corey Kiner chipped in 45 yards on 10 carries, while Jordan Watkins hauled in three catches for 56 yards. Starter Brock Purdy didn't suit up last week, but head coach Kyle Shanahan hinted that some first-stringers — including Purdy — could get live reps against the Chargers.
Injuries have been the recurring theme of the Niners’ preseason. Nick Bosa, Jauan Jennings, Isaac Guerendo, and rookie Mykel Williams were among those sidelined in Tuesday’s session. Still, one bright spot has been cornerback Chase Lucas, who’s been everywhere through two games. He leads the team in snaps played and has stuffed the stat sheet with 10 tackles, two pass breakups, an interception, a sack, and even a safety — a breakout preseason that’s raising eyebrows about whether it’s a blessing or a warning sign.
Los Angeles Chargers team news
Even in defeat, Los Angeles has been encouraged by what they've seen from Trey Lance. The former No. 3 overall pick went 7-for-15 for 121 yards this past weekend, adding 25 yards on four scrambles.
Once the face of San Francisco's future, Lance's career was derailed by injuries and inconsistency, leading to a trade to Dallas where he spent two seasons buried on the depth chart. Now in L.A., he's fighting to re-establish himself as a reliable QB2.