The Arizona Cardinals (2-0) travel to Levi’s Stadium on Sunday afternoon for a key NFC West clash with the San Francisco 49ers (2-0).
49ers vs Cardinals date and start time
The 49ers and the Cardinals will meet in Week 3 of the NFL season at Levi's Stadium in Santa Clara, California, on Sunday, September 21, starting at 4:25 pm ET / 1:25 pm PT for fans in the US.
| Date | Sunday, September 21, 2025 |
| Kick-off Time | 4:25 pm ET / 3:25 pm CT/ 1:25 pm PT |
| Venue | Levi's Stadium |
| Location | Santa Clara, California |
How to watch 49ers vs Cardinals on TV & stream live online
- National TV channel: FOX
- Streaming service:Fubo
Arizona is coming off a shaky 27-22 win over Carolina, where they nearly squandered a massive 24-point cushion as the Panthers stormed back with 13 unanswered points in the fourth quarter.
San Francisco, meanwhile, edged past New Orleans 26-21 on the road. With Brock Purdy sidelined by a shoulder issue, Mac Jones stepped up, tossing for 279 yards and three touchdowns.
Here, GOAL brings you everything you need to know about how to watch the 49ers vs Cardinals.
READ MORE: 49ers vs Cardinals NFL Preview: Team news, betting, tickets, live stream, Fantasy Football and more
In the US, the 49ers vs Cardinals is going to be broadcast on FOX, which is available with most cable packages and on our favorite streaming service, Fubo, which is currently offering a free trial to new subscribers.
Watching NFL action this season just got easier and more versatile, with a mix of traditional TV broadcasts and exclusive streaming options. When it comes to convenience and coverage, Fubo stands out as one of the most user-friendly ways to catch nearly every down and touchdown.
With access to nearly 200 channels, Fubo lets fans tune in to all the key networks that carry NFL games, including CBS, NBC for Sunday Night Football, Fox for Sunday NFC clashes, ABC, ESPN for Monday Night Football, and the NFL Network. That means you’re covered for almost every regular season and playoff matchup. Want even more action? You can tack on NFL RedZone for an extra $11/month and stay locked into every scoring drive from around the league on Sundays.
While Amazon Prime Video remains the exclusive home for Thursday Night Football in 2025, fans in local team markets can still stream those primetime matchups through Fubo, making it a flexible all-in-one option. And it's not just football — Fubo is loaded with sports content. From MLB, NBA, and NHL games to MLS and international soccer, there's something for every fan year-round.
READ MORE: Fubo Review: Pricing, plans, subscriptions, free trials and more
Watch highlights of the 49ers vs Cardinals
Highlights, live updates and scores from the Week 3 matchup between the 49ers and the Cardinals will be available on NFL.com, the league's official YouTube channel, and across each team's social media platforms. ESPN+ also gives you access to non-stop NFL action all season long, with live games, originals, highlights, and more. Follow along.
NFL+ is the go-to spot for fans who want to relive full games ad-free or catch live local and primetime matchups. What used to be free on the old NFL app now comes with some extra perks — including access to NFL Network and, on the Premium tier, the always-addictive NFL RedZone.
At just $7 a month, the base plan gets you live in-market and primetime games on your phone or tablet, plus ad-free NFL Films and other on-demand content. But the real prize is RedZone — a must-have for fantasy diehards who want to keep tabs on every scoring drive across the league. At $15 for Premium, it's the most affordable way to get it.
Adding to the streaming shake-up, ESPN is rolling NFL+ Premium into its new Unlimited bundle. That package, which also includes RedZone, runs $39.99 per month.
Streaming the game with a VPN
Unable to watch this game due to broadcast restrictions? A VPN could be the answer to your problems.
You can watch the game from wherever you are in the world by using a VPN (Virtual Private Network) service such as Express VPN. A VPN will allow you to create a secure connection online when you are abroad on holiday or for work, and you want to stream the game live. You can eventry ExpressVPN risk-freewith a 30-day money-back guarantee.
If you are not sure which VPN to use or how to use a VPN, we have taken a look at the best options available out there for watching live sports - check out the best VPN services review here.
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- Cardinals 2025 NFL schedule: TV channel, livestream & where to watch the games
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