We’re backing the Gunners to get the job done back on home soil, with the Germans unlikely to go down without a fight.
Best Predictions for Arsenal vs Bayer Leverkusen
- Arsenal to win and over 2.5 goals @ -118 with bet365
- Both teams to score @ +110 with bet365
- Viktor Gyokeres as anytime goalscorer @ +120 with bet365
All odds are courtesy of bet365, correct at the time of publishing and subject to change.
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Our analysis: Form of both teams
Score prediction - Arsenal 2-1 Leverkusen
Goalscorers Prediction - Arsenal: Viktor Gyokeres, Bukayo Saka - Leverkusen: Christian Kofane
Arsenal continued their fantastic form over the weekend, beating Everton to extend their unbeaten run to 13 matches across all competitions. The Gunners have won eight of their nine matches in the Champions League, as well. Consequently, the Premier League leaders will be full of confidence heading into this Round of 16 tie.
Their opponents have proven difficult to beat, though. Bayer Leverkusen may have won only one of their previous six games, but they’ve suffered just one defeat in their last 14 matches. Following a 1-1 draw against Bayern Munich, they’ll be confident of causing some problems for Mikel Arteta in this match.
Probable lineups for Arsenal vs Bayer Leverkusen
Arsenal expected lineup: Raya, Mosquera, Saliba, Gabriel, Hincapie, Zubimendi, Rice, Madueke, Saka, Martinelli, Gyokeres
Bayer Leverkusen expected lineup: Blaswich, Andrich, Quansah, Tapsoba, Poku, Fernandez, Palacios, Grimaldo, Maza, Terrier, Kofane
Arsenal to progress in a high-scoring game
Arsenal are in strong form this season. They are currently chasing a long-awaited Premier League title, and are unbeaten in the Champions League. While Bayer Leverkusen managed to stop them from winning in the first leg, it is unlikely to happen this time.
The home side are not quite at full strength, with concerns over the fitness of Martin Odegaard, Jurrien Timber, and Leandro Trossard. Additionally, Mikel Merino is definitely unavailable for this clash. However, Arsenal possess significant squad depth this season and should be capable of handling this challenge, especially on home soil.
Regarding the visitors, Kasper Hjulmand has several selection issues to address. Aleix Garcia and Martin Terrier are the latest injury concerns. Meanwhile, Mark Flekken, Loic Bade, Arthur, Lucas Vazquez, and Eliesse Ben Seghir remain absent. The German outfit will face a very difficult challenge in London.
- Arsenal vs Bayer Leverkusen Prediction 1: Arsenal to win and over 2.5 goals @ -118 with bet365
Resilience from the visitors
The hosts are certainly in better form, but Die Werkself are known for being difficult to beat. Hjulmand’s men have lost only one in 14 games across all competitions, and scored in 12 of them. Also, with a variety of different goalscorers, it’s tough to focus on one particular threat.
Even with their good run, Arsenal’s defence can be vulnerable. They have managed only three clean sheets in their last nine games, and Leverkusen did score against them last week. This certainly seems like a match in which both teams are likely to score.
We’re backing the Londoners to come out on top, but it won’t be easy. It should be a great game for neutral fans once again.
- Arsenal vs Bayer Leverkusen Prediction 2: Both teams to score @ +110 with bet365
Gyokeres to find the net again
Some have criticised Viktor Gyokeres, but it seems unwarranted. The 27-year-old has recorded 16 goals in his debut campaign for the Gunners, with four of those coming in seven UCL appearances. He was rested during the weekend game against Everton but still came off the bench to score.
Arsenal have shared the goals around during the 2025/26 season, but the Swedish striker is their leading scorer. He is the bookies’ favourite to score in this match, and we agree. Gyokeres has scored some crucial goals for Arsenal, and we are backing him to score another one this weekend.
- Arsenal vs Bayer Leverkusen Prediction 3: Viktor Gyokeres as anytime goalscorer @ +120 with bet365