The South Americans, meanwhile, beat Italy last week 2-0 although manager Jorge Sampaoli knows defeat against another contender would be a big blow for morale.
Spain are unbeaten since Lopetegui took over as manager 17 matches ago and dabblebet offer them at evens (2.00) for the win.
Top scorer in the current squad David Silva has withdrawn from the squad for personal reasons, making Andres Iniesta and Sergio Ramos the only players in the 23-man squad with more than ten international goals.
Lionel Messi sat out La Albiceleste's win over Italy with a knock and is set to miss out again here.
Spain good value on home soil
Spain's first game at the World Cup is against Portugal on 15 June and Lopetegui seems close to having a starting eleven already decided.
The likes of Diego Costa and Iago Aspas are battling it out to start up front, but otherwise La Roja are set and should be able to see off an experimenting Argentina side.
Indeed, Sampaoli is yet to really decide on how to set up his men and prior to the win over Italy, the South Americans had looked surprisingly poor.
In their two friendlies in November, they edged past Russia 1-0 with a late strike before surrendering a two-goal lead to lose 4-2 against Nigeria, so there are still plenty of question marks before the World Cup.
Preview and predictions
Therefore, the price of evens (2.00) for them to win at home against an Argentina team who fail to really convince looks like a promising option.