Barcelona's last home match in La Liga two weeks ago saw their 42-game unbeaten run come to an end, as Real Betis became the first side to win a league encounter at the Camp Nou since September 2016.
Last weekend the champions needed a late goal to salvage a draw from their trip to Atletico Madrid, a result which saw them cede top spot in the table to Sevilla.
Villarreal meanwhile head to Catalonia looking for the third away win of the season, and the Yellow Submarine have enjoyed much more success on the road this term than in their own stadium.
Latest odds
Barca have won each of the last seven league games against Villarreal at home and bet365 offer them at 1/4 (1.25) to extend that winning run. The visitors' last win at the Camp Nou came in 2008 and they are priced at 10/1 (11.00) with the draw at 11/2 (6.50).
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Team news
Barcelona will still be missing striker Luis Suarez, while midfielders Rafinha and Sergi Roberto are out and Arthur remains a doubt.
Villarreal have suffered a number of injuries this season, yet with players recovering from their various problems, only midfielders Bruno Soriano and Javi Fuego remain missing.
Preview
Barcelona have been a little erratic by their lofty standards this season, with the champions suffering some unexpected results. There has however been a constant theme in their home league matches where the Blaugrana have badly struggled for clean sheets.
GoalSince the 3-0 win over Alaves on 18th August, the Catalans have failed to keep a clean sheet at the Camp Nou in La Liga. Barca's total of 12 goals conceded in their own stadium in the third highest total in the division, while Villarreal have scored in each of their last five away games in the Spanish top-flight.
Tips and predictions
Backing goals at both ends is available at 3/4 (1.75) which is a price worthy of consideration given the sides' respective records. A home win and both teams to score should also be of interest at 7/5 (2.40).
Both teams to score at 3/4 (1.75) for a 2.5pt stake with bet365