Real Madrid can take another step towards a first league title since 2011-12 by beating Granada in the Primera Division on Saturday night.
Zinedine Zidane's side dropped to second place in the table after losing the Clasico to Barcelona last month, but Los Blancos still have a game in hand over their fierce rivals.
Barca are at home to Villarreal on Saturday evening, with Madrid in action straight afterwards in Granada. The Catalans have just three games left including that one, with four still to play for Real.
REAL MADRID INJURIES
Raphael Varane has had a setback and will play no part against Granada, while Pepe is back in training but not quite ready to return for the weekend match.
REAL MADRID SUSPENSIONS
Cristiano Ronaldo, Carvajal and Isco are all just one yellow card away from a ban, but the Portuguese has been rested ahead of the Champions League anyway and the Spain defender is out injured.
With a tough game against Sevilla ahead next weekend, Zidane may also decide to keep Isco in reserve to avoid a booking that would see him miss that match.
REAL MADRID POTENTIAL STARTING LINE-UP
With the Champions League semi-final second leg against Atletico coming up on Wednesday, Zidane will keep most of his first-choice players in reserve for Saturday's match in Granada.
Ronaldo has been left out of the squad altogether and Karim Benzema is set to be rested, along with Casemiro, Isco, Luka Modric and Marcelo.
Kiko Casilla will start in goal as Keylor Navas is also rested, but Sergio Ramos will be needed because Pepe and Varane are unavailable.
GRANADA TEAM NEWS
Granada have already been relegated after four consecutive defeats under interim coach Tony Adams and will be playing for nothing more than pride (and to avoid finishing bottom) in this match.
The Andalusian side are down in 19th place, just one point above Osasuna with three matches left to play.
Adrian Ramos, Dimitri Foulquier and Gaston Silva are all set to miss the game against Madrid through injury, while Matthieu Saunier, Artem Kravets and Hector Hernandez are doubtful after all three were absent in the defeat at Real Sociedad at the weekend.
Barcelona loanee Sergi Samper is also unlikely to feature again as the club look to save funds ahead of their return to the Segunda Division and are paying the Catalan club more money every time the midfielder appears in the first team.
BEST OPTA MATCH FACTS
Granada have lost 13 of their last 14 games versus Real Madrid in La Liga. Their only win was in February 2013 thanks to an own goal scored by Cristiano Ronaldo.
Granada are without a win in 10 games in La Liga (drawn one, lost nine), the worst current run of any Primera Division team.
Karim Benzema has scored at least once in each of his last seven appearances against Granada in La Liga (eight goals).
Guillermo Ochoa has made more saves (152) and conceded more goals (74) than any other goalkeeper in the top five European leagues this term.
UK TV COVERAGE & KICK-OFF TIME
Granada versus Real Madrid kicks off at 20:45 CEST and will be shown live from 19:30 UK time on Sky Sports 5 straight after Barcelona's game against Villarreal on the same channel.