Zinedine Zidane's side beat PSG 3-1 at the Santiago Bernabeu to take a significant step towards the quarter-finals of the European competition, although they still face a tought trip to the Parc des Princes next month.
In the Primera Division, Los Blancos are well adrift in fourth place, 17 points behind leaders Barcelona after 23 rounds of the championship, albeit with a game in hand.
A win at Betis on Sunday will see Real move into third place in the table if Valencia fail to beat Malaga away earlier on in the day. Here, a look at everything you need to know before Madrid's game at the Benito Villamarin...
REAL MADRID INJURIES
Defender Jesus Vallejo is still sidelined with a muscle problem and midfielder Toni Kroos is also out after picking up a knee injury against PSG that could make him doubtful for the trip to Paris on March 6th.
REAL MADRID SUSPENSIONS
Dani Carvajal was suspended for the Champions League clash against PSG, but he returns in La Liga and Zidane has no players banned for the meeting with Betis.
REAL MADRID POTENTIAL STARTING LINE-UP
With Carvajal back from a European ban, he will return to the side on the right side of defence. But over on the left, Marcelo is likely to be rested after his impressive display on Wednesday, with Theo Hernandez in line to start instead.
Nacho could partner Ramos in the centre, while there will be at least one change in midfield as Kroos misses out through injury.
Marco Asensio and Lucas Vazquez are both in contention for starting spots after starring from the bench on Wednesday, while Gareth Bale should feature from the outset instead of Karim Benzema, who was disappointing again versus PSG.
BETIS TEAM NEWS
Following something of a dip in form, Betis are back on song in La Liga and have won their past two matches in the competition: at home to Villarreal and away to Deportivo La Coruna.
Quique Setien's side surprised Real Madrid by beating Los Blancos 1-0 at the Santiago Bernabeu earlier this season and the Betis boss said ahead of this match that his side have "a real chance" of repeating that success in Sunday's home fixture.
Setien will be without forwards Joel Campell and Antonio Sanabria, as well as defender Zouhair Feddal (all injured) for this match, while winger Francis is doubtful.
TV COVERAGE & KICK-OFF TIME
Betis versus Real Madrid kicks off at 20:45 local time on Sunday, with viewers in the United Kingdom (UK) able to watch live on Sky Sports Main Event and also on Sky Sports Football from 19:40 GMT.
In the United States (US), the match is live on beIN Sports and kicks off at 14:45 ET.
BEST OPTA MATCH FACTS
After their 1-0 win at the Santiago Bernabeu in September 2017, Betis have the chance to win two games against Real Madrid in the same La Liga season for the first time since 1998-99.
Betis have only won two of their last seven La Liga games at home, failing to keep a clean sheet in all of those.
Real Madrid have had more different goalscorers than any other side in La Liga this season (15).
Cristiano Ronaldo has scored seven goals in the second half of La Liga so far, more than any other player.
Quique Setien has only lost two of his five games against Real Madrid as a coach (winning one and drawing two) and has avoided defeat in the last three of those.