Jurgen Klopp's men have 70 points after 36 games of the Premier League season and, should they secure six points from their final two fixtures, their tally of 76 would be enough to guarantee a top four finish - and qualification for next season's Champions League.
Despite failing to take maximum points against the Saints, Liverpool come into this match in fine form. Klopp's men have lost just one of their last 10 Premier League fixtures, with the Reds taking 10 points from their last four games away from home.
West Ham, though, will provide a stern test for Liverpool - the Hammers are unbeaten in their last five fixtures and Slaven Bilic's side will be in buoyant mood after effectively ending Tottenham Hotspur's push for the Premier League title with a win against Mauricio Pochettino's men last time out. The home side can be backed at 4/1 (5.0) to double their delight with victory in this one.
Furthermore, West Ham have kept a clean sheet in four of their last five fixtures and the odds compilers offer 9/2 (5.50) that Klopp's side draw a blank in east London and 8/1 (9.0) that West Ham win to nil - a selection that would have seen punters profit from all but one of the 10 home wins that the Hammers have enjoyed in all competitions this season.
There have been fewer than two goals scored in three of Liverpool's last four matches, with the Reds claiming vital 1-0 victories in both of their last two matches away from Anfield. There is 15/2 (8.50) that Klopp's men make it a hat-trick of 1-0 wins when they visit London Stadium, while 3/1 (4.0) is available that there are fewer than two goals scored.
Four of the last five fixtures that the Hammers have fulfilled have seen fewer than two goals scored and that play may well prove popular with punters again ahead of this clash.
Better value, though, may lie in backing fewer than three goals to be scored when the rivalry is renewed in east London - a tight, tense clash seems likely, but backing no more than two goals allows punters more flexibility than the Under 1.5 goals market.
As such, it is bet365's 43/40 (2.08) quote for fewer than three goals to be scored that could offer best value ahead of Sunday's crucial clash.