Marcus Rashford was named ahead of Anthony Martial in Manchester United's starting XI against Stoke City on Saturday.
The England international comes into the game on the back of his match-winning display for the Three Lions against Slovakia on Monday, and is preferred to Martial.
The Frenchman came off the bench to net late goals against West Ham and Swansea, while Martial started the last game against Leicester at Old Trafford before Rashford came off the bench to score the opening goal in a 2-0 win.
Elsewhere, Matteo Darmian comes in for Daley Blind at left-back, while Ander Herrera makes his first league start of the season ahead of compatriot Juan Mata as Jose Mourinho changes shape to a likely 4-3-3 formation.
United will look to make it four wins from four Premier League games when they take on the Potters at the bet365 Stadium.
Man Utd XI: De Gea, Valencia, Bailly, Jones, Darmian, Matic, Pogba, Herrera, Mkhitaryan, Rashford, Lukaku
Subs: Romero, Blind, Smalling, Carrick, Mata, Lingard, Martial
Stoke City XI: Butland; Cameron, Zouma, Wimmer; Diouf, Fletcher, Allen, Pieters; Shaqiri, Jese; Choupo-Moting
Subs: Grant; Berahino, Tymon, Martins Indi, Adam, Crouch, Ramadan.