The Swiss are set to take on Ireland and Gibraltar next week as they aim to reach Euro 2020, but they will have to do so without the 27-year-old, who has 82 caps in his international career.
Shaqiri made 24 appearances in the Premier League last season, his first campaign with the Reds after joining from Stoke City.
This season, however, Shaqiri has only made one appearance for Liverpool, which came in the Community Shield against Manchester City earlier this month.
After being an unused substitute in Liverpool's first three Premier League games, manager Jurgen Klopp has insisted that Shaqiri will have a major role to play this season.
Unser Aufgebot für die Spiele gegen Irland und Gibraltar— nationalteams_SFVASF (@SFV_ASF) August 30, 2019
Voici notre sélection pour les matches contre l'Irlande et Gibraltar
Ecco i nostri convocati per le partite contro l'Irlanda e Gibilterra
🎫 Achète ton billet pour le match à Sion sur https://t.co/bn2xFql5fQ ! pic.twitter.com/x58t0LG81Z
"It's the first four weeks of the season, that's how it is. That's probably the hardest period for players who are not [playing]," Klopp said at a press conference on Friday.
"In training, Shaq doesn’t have to improve in any way if he can keep the level he is doing at the moment.
"Of course he can improve like how everybody can improve, but it's not about that – he doesn't have to show anything special.
"We will need him, he knows that 100 per cent."
Klopp has admitted that Shaqiri is not happy with his role in the early season, but says that the Swiss attacker hasn't let that affect him in training.
"Is he the happiest player in the squad? I don't think so. Can I see that on the training pitch? No.
"He is in a good mood, training hard, doing what he has to do and is ready for the moment when he has to help the team on the pitch."
Liverpool have won all three of their Premier League matches so far this season, and look to make it four from four on Saturday when they take on Burnley.