There has been no report of any physical problem for the 35-year-old, who has scored in his last 11 fixtures in all competitions, including a club record 11 successive Serie A matches.
He has been chasing the all-time mark of Fiorentina hitman Gabriel Batistuta, who scored in 11 consecutive matches at the beginning of the 1994-95 campaign, which extends to 13 if the end of the previous season is included.
Juventus have not got a prolific scorer in their ranks other than the Portuguese. Their second-leading marksmen are Gonzalo Higuain and Pablo Dybala, who each have five Serie A goals in 21 outings.
His absence represents a particular blow for Maurizio Sarri’s side given that they are in the midst of a difficult run of form, having won only one of their last four matches in all competitions, including costly league defeats against Napoli and Verona.
The Turin giants find themselves in the unfamiliar role of playing catch up in the Serie A standings, albeit they only trail Antonio Conte’s Inter on goal difference - the league leaders have scored four more goals than Juve and have conceded three fewer.
Juventus will also be without Douglas Costa, Federico Bernardeschi, Sami Khedira, Giorgio Chiellini and Merih Demiral, who are all still missing with injury complaints.
After playing Brescia on Sunday, Juventus visit SPAL next weekend then face a Champions League trip to Lyon, a home match against Serie A leaders Inter and the second leg of their Coppa Italia tie against Milan in the space of a week that has the potential to be season defining for the Bianconeri.