Real Madrid welcome Villarreal to the Estadio Alfredo Di Stefano on Thursday evening with Zinedine Zidane's men knowing a win will see them wrap up another La Liga title.
Los Blancos could even drop points and still be crowned champions if Barcelona fail to beat Osasuna at Camp Nou, although Madrid will surely want to seal it with a victory.
Real Madrid vs Villarreal Latest Odds
Los Blancos are unbeaten at home this season in La Liga and bet365 price the hosts at 2/5 (1.40) to claim another victory.
Madrid, however, have only won two of the last seven matches against the Yellow Submarine and the previous meeting this season saw the sides play out a 2-2 draw.
Another stalemate is priced at 4/1 (5.00) with the visitors at 13/2 (7.50) .
Real Madrid vs Villarreal Team News
The 33-time La Liga winners are likely to be without injured trio Marcelo, Nacho Fernandez and Mariano Diaz, although Luka Jovic could return to the squad.
Villarreal will welcome back top scorer Gerard Moreno from suspension but are without injured forward Carlos Bacca, while Paco Alcacer is also a doubt.
Real Madrid vs Villarreal Preview
Nine wins in a row have put Zidane's side within touching distance of the title and even when they have not played well, they have found a way to win.
Thursday evening could be the definitive night in the title race but it also sees Real Madrid come up against the best side they have had to face since the resumption of the season.
The Yellow Submarine have been playing well and sit fifth in the table, whilst being the third-top scorers in the division behind Real and Barcelona.
Javi Calleja's men have scored in 33 of their 36 matches this term as well as in each of their last seven matches against Madrid and while Los Blancos have been in excellent defensive form, there could be a temptation to back the visitors to find the back of the net.
Real Madrid vs Villarreal Tips and Predictions
Both teams to score is have paid out in six of the last seven clashes between these two sides and a repeat is appealing at 3/4 (1.75) .
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Odds correct at the time of writing. Please gamble responsibly.
Both teams to score at 3/4 (1.75) for a 1pt stake with bet365 