Seattle will be looking to get their season back on track after starting the campaign 3-2, while their rivals the San Francisco 49ers remain undefeated at the top of the NFC West. Denver are also second in their division with a 3-2 record. A win could see them back in the fight for the AFC West title versus the Kansas City Chief and Las Vegas Raiders.
Broncos vs Seahawks Predictions, Picks & Odds - 8:15pm ET - 10/15/2026
- Seattle Seahawks - 2.5 @ -120 with BetMGM
- Under 40.5 Points @ -110 with BetMGM
- Jaxon Smith-Njigba Anytime Touchdown @ +110 with BetMGM
All odds are courtesy of BetMGM, correct at the time of publishing and subject to change.
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Seattle Seahawks - 2.5
While both Seattle and Denver have the same records coming into this game, it’s the Seahawks who have been the more convincing side this season. In fact, the Broncos have been lucky to only have two losses this year.
Denver has the lowest points differential of any team in the NFL with a winning record — they are just one of two teams with a winning record to have a negative points differential (-14). The Broncos have also been down at half-time in four of their five games this season.
Seattle, meanwhile, have an astonishing 21-3 record when leading at half-time since head coach Mike Macdonald took over the team in 2024. All three of those losses came in his first season. The Seahawks also have the league’s best defense, allowing just 1,256 yards against in five games.
- Broncos vs Seahawks Pick 1: Seattle Seahawks - 2.5 @ -120 with BetMGM
Under 40.5 Points
Besides surprising half-time comebacks, another trend for Denver this season is that they don’t score a lot of points. The Broncos have scored just 97 points this season and have scored only nine offensive touchdowns this season. They rank 26th in the NFL for both stats and 27th for the average number of plays per drive, with 5.6.
Seattle’s defense leads the NFL in turnovers (11) and has allowed the third-fewest first downs this season (80). When you put this together with Denver’s poor offensive record, it’s going to be a long night for the Broncos’ offense.
Additionally, the under has hit in four of Denver’s five games this season. If you zoom out even further, the under has hit in seven of the Broncos’ last 10 games dating back to last year.
- Broncos vs Seahawks Pick 2: Under 40.5 Points @ -110 with BetMGM
Jaxon Smith-Njigba Anytime Touchdown
The only thing stopping Sam Darnold from having a solid game against the Broncos are turnovers. Seattle have committed nine TOs this year, including four against the 49ers last weekend.
If the Seahawks can clean up their mistakes, their offense shouldn’t have any problems dealing with Denver’s inconsistent defence. And, if that happens, expect Darnold to look for Smith-Njigba often.
The 2026 AP NFL Offensive Player of the Year ranks third in receptions, first in receiving yard, and has already scored a league-leading seven touchdowns this season.
- Broncos vs Seahawks Pick 3: Jaxon Smith-Njigba Anytime Touchdown @ +110 with BetMGM
Broncos vs Seahawks at US Prediction Markets
US sports traders can buy options on the Week 6's opening Thursday Night Football clash between the Denver Broncos and Seattle Seahawks across all of the best prediction market apps.
Traders across all major exchanges are expecting a close game, with the Seahawks narrow favorites at 57¢ on Novig, Kalshi, and Polymarket. With the Broncos at 44¢, and only a 2.5 point spread, the market is split on who'll collect the win.
The 50¢ mark for the U/O is surprisingly low at 40.5 points, too. With a pair of strong defenses and faltering offenses on display, traders are clearly not expecting a busy night for the scorekeepers.
All prices correct at time of publication and subject to change.
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Broncos vs Seahawks Start Time
The Seahawks travel to Denver for a Super Bowl XLVIII rematch against the Broncos at Empower Field at Mile High. You can watch this Thursday Night Football (10/15) matchup at 8:15 ET (6:15pm Local Time) live on Amazon Prime Video.
Broncos vs Seahawks Game Details
Start Time: 8:15 ET (6:15pm Local Time)
Location: Empower Field at Mile High
Address: 1701 Bryant St, Denver, CO 80204, United States
Streaming: Amazon Prime Video