Salah will depart Merseyside after Saturday's match and switch focus to international football. Egypt take on Nigeria in a friendly before AFCON starts and then face Zimbabwe, Angola and South Africa in the group phase. If Egypt make it all the way to the final, then Salah is set to be away from Liverpool until at least January 18.
During his absence, his agent - Ramy Abbas - is set to hold talks with Liverpool over the 33-year-old's future at the club, according to BBC Sport. Salah signed a new two-year contract in the summer but it remains to be seen if he will now see that out.
In the meantime, Liverpool face a busy fixture list over festive period and into January with games against Tottenham, Wolves, Leeds United, Fulham, Arsenal and Burnley in the Premier League as well as an FA Cup third round tie against Barnsley.