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49ers vs Colts Predictions
Liam Isola

49ers vs Colts Predictions - NFL Monday Night Football Dec 22nd

Our NFL expert offers his 49ers vs Colts predictions, picks, and odds for a Monday Night Football matchup at 8:15pm EST in Indianapolis (12/22).

Philip Rivers and the Indianapolis Colts (8-6) still have playoff hopes, and they’ll be looking to upset the San Francisco 49ers (10-4, -5.5) on Monday Night Football. With 44-year-old Rivers at the helm, the Colts will manage the clock, and under 46.5 points (-110) could hit as a result.

49ers vs Colts Predictions - 8:15pm EST - 12/22

  • Jonathan Taylor 125+ Rushing Yards @ +190 
  • Under 46 Points @ -110
  • Colts +5.5 @ -102

All odds are courtesy of US Sportsbooks, correct at the time of publishing, and subject to change.

49ers vs Colts Odds

  • Spread: 49ers -5.5 (-118)
  • Moneyline: 49ers (-250), Colts (+200)
  • Total: O/U 46 (-110)

49ers vs Colts Picks

Taylor to Carry Colts’ Offense - Jonathan Taylor 125+ Rushing Yards (+175)

Last Sunday against the Seahawks, Jonathan Taylor carried the ball 25 times, which is tied for his second-most touches of the season. Taylor currently leads the NFL in both rushing yards (1,443) and carries (272).

With new QB Philip Rivers still learning the playbook, it’s only natural to assume Taylor will get plenty of carries again tonight. The 49ers have also looked weak against the run lately, especially in the recent win against the Titans, in which Tennessee picked up 6.8 yards per carry.

Taylor averaged 5.3 yards per carry, and if he gets 25 carries again tonight, he’s got a good chance to have a 125-yard rushing game (+175). It’s something he’s done three times this season already, and may need to do if the Colts are going to push the Niners tonight.

  • 49ers vs Colts Prediction 1: Jonathan Taylor 125+ Rushing Yards @ +175

Clock Management Should Lead to an Under - Under 46 Points (-110)

Philip Rivers is a literal grandpa playing NFL football. The 44-year-old Colts quarterback, who recently unretired after nearly five years away from the game, will not do anything flashy tonight. Rivers and the Colts, as they did in an 18-16 loss against the 49ers, will try to manage the clock.

Again, this game of keep away will lead to plenty of carries for running back Jonathan Taylor. Plus, the Colts’ defense still ranks as one of the best run-stop units in the league. In fact, they give up fewer yards per carry than any other team in the league.  

Things haven’t been all bad for the Colts on this four-game losing streak, as they’ve allowed more than 20 points only once. The 49ers, on the other hand, have won four straight games while averaging 31 points.

Still, the combined record of the teams the Niners have played on their winning streak is 15-41. The Colts will do enough defensively to keep the total under 46 points (-110).

  • 49ers vs Colts Prediction 2: Under 46 Points @ -110

Colts Can Keep it Close - Colts +5.5 (-102)

It would only be natural for the Colts to feel disrespected by this line. Yes, quarterback Daniel Jones is now out for the season, but they’ve still managed a 5-1 record at home.

Their only loss was by a four-point margin against the Texans, who have the best scoring defense in the NFL. Last Sunday, the Colts traveled to Seattle as 13-point underdogs against the Seahawks, who have another elite defense, and only lost by two points.

The 49ers are nowhere near elite on defense, as they rank second-to-last in opponent run success rate. On the other side of the ball, Niners QB Brock Purdy has also had an injury-plagued season and hasn’t been at his best.

Colts RB Jonathan Taylor is absolutely key here. If he can string together some big runs, and Rivers can get some small gains here and there, the Colts have a chance to win this one. Don’t hesitate to take the Colts +5.5 (-110)

  • 49ers vs Colts Prediction 3: Colts +5.5 @ -102

49ers vs Colts Start Time

  • Start Time: 8:15pm EST
  • Location: Lucas Oil Stadium
  • Address: 500 S Capitol Ave, Indianapolis, IN 46225
  • TV & Streaming: ABC, ESPN, Fubo, Hulu, Sling TV, YouTube TV, NFL+

Brock Purdy and the San Francisco 49ers are looking for a fifth straight win as they try to stay afloat in a highly competitive NFC West division. The Colts are coping without QB Daniel Jones and looking to break a four-game losing streak of their own.