The rivals will meet at NRG Stadium in Houston as part of the International Champions Cup on July 20, the clubs announced Monday.
“The Manchester Derby is one of the world's most iconic games,” City chief executive Ferran Soriano said in a club release. “We are very excited to play it in front of our passionate American fans. There are so many great memories from this game in history and we can't wait to create some new ones in Houston."
United have previously played in what is now known as NRG Stadium, having defeated the MLS All-Stars 5-2 in 2010. That match featured a sell-out, something the clubs are hoping to re-create for July's contest.
"The game in Houston gives our large US family of fans another chance to see the team play live,” United executive vice-chairman Ed Woodward said. “The last time we played in Houston, over 70,000 packed the stadium and we are looking forward to entertaining them again.”
United, meanwhile, will take on the LA Galaxy at StubHub Center in Carson, California; Real Salt Lake at Rio Tinto Stadium in Sandy, Utah; Real Madrid at Levi's Stadium in Santa Clara, California; and Barcelona at FedEx Field in Landover, Maryland.