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Colts vs Chargers Predictions
Liam Isola

Colts vs Chargers Predictions, Picks & Odds: NFL Sunday Week 7

Our NFL expert offers his Colts vs Chargers predictions, picks, and odds as AFC Division leaders face off at 4:05pm EDT at SoFi Stadium (10/19).

The only loss the Indianapolis Colts (5-1) have suffered this season was to the Rams at SoFi Stadium. Now, the Colts return to SoFi as 1.5-point underdogs for a Week 7 game against the Los Angeles Chargers (4-2).

Colts vs Chargers Predictions - 4:05pm EDT - 10/19

  • Jonathan Taylor Over 88.5 Rushing Yards @ -115 with BetMGM
  • Under 43.5 Points @ -110 with BetMGM
  • Colts ML @ +110 with BetMGM

All odds are courtesy of BetMGM, correct at the time of publishing, and subject to change.

Colts vs Chargers Odds

  • Spread: Chargers -1.5 (-110)
  • Moneyline: Colts (+110), Chargers (-130)
  • Total: O/U 48.5 -110

Colts vs Chargers Picks

Taylor Tough to Contain - Jonathan Taylor Over 88.5 Rushing Yards (-115)

Running backs have been tearing up the Chargers’ defense lately. The Dolphins’ De’Von Achane went for 128 yards and 2 TDs on just 16 carries in a 29-27 loss last Sunday. The weekend before, the Commanders’ Jacory Croskey-Merritt picked up 111 rushing yards against LA.

Over the last four games, the Chargers’ opponents have been averaging 144.8 rushing yards per game. That should be music to Jonathan Taylor’s ears. The Colts running back leads the NFL in carries (115), rushing yards (603), and rushing touchdowns (7).

As long as Taylor is somewhat near his season average of 5.2 yards per carry today, he should have no problem getting 90+ rushing yards. Bet on Taylor to pick up over 88.5 rushing yards at -118 odds.

  • Colts vs Chargers Prediction 1: Jonathan Taylor Over 88.5 Rushing Yards @ -115 with BetMGM

Offense Over Defense - Over 48.5 Points (-110)

The Indianapolis Colts have the most efficient offense in the NFL. They lead the league in points per game (32.3) and points per play (.537). Indianapolis also ranks in the top five for fewest opponent points per game, but they haven’t played a team that ranks higher than 16th in PPG.

Los Angeles has had to adjust to losing its top two running backs (Najee Harris and Omarion Hampton) to injuries, but Kimani Vidal has filled in admirably. The Chargers’ offense looked competent as Vidal ran for 124 yards on 18 carries in the 29-27 Week 6 win over the Dolphins.

Indy gave up 27 points to the Cardinals last weekend, Arizona’s joint-highest total of the season. There’s certainly room for both teams to have success on offense, and the Colts’ QB-RB duo of Daniel Jones and Jonathan Taylor has been exceptional this season.

Expect a fair amount of scoring here and bet on over 48.5 points.

  • Colts vs Chargers Prediction 2: Over 48.5 Points @ -110 with BetMGM

All in on Indy - Colts ML (+110)

So far, the Chargers have been one of the worst teams in the NFL at stopping the run. Opponents have averaged five yards per carry against LA this season, and 5.2 YPC over the last four games. Meanwhile, Indianapolis ranks sixth in the NFL, with 131.8 rushing yards per game.

Colts RB Jonathan Taylor could have a field day against the Chargers’ weak running defense. Also, Chargers linebacker Khalil Mack remains out, which hampers their ability to get to Colts QB Daniel Jones.

Indianapolis has played a weak schedule so far this season, but it should still be able to put up a lot of points against an injury-stricken Chargers team. The Colts are beating opponents by an average of 13 points per game, which leads the NFL.

Indy should be able to avoid a second loss of the season at SoFi today and hand the Chargers a third loss in their last four games. Take the Colts’ moneyline.

  • Colts vs Chargers Prediction 3: Colts ML @ +110 with BetMGM

Colts vs Chargers Start Time

  • Start Time: 4:05pm EDT
  • Location: SoFi Stadium
  • Address: 1001 Stadium Dr, Inglewood, CA 90301
  • TV & Streaming: CBS, Paramount+, Fubo, Hulu, YouTube TV, NFL+

In recent weeks, the Los Angeles Chargers have been decimated by injuries and have lost two of their last three games. Today, the Chargers host an Indianapolis Colts team with the league’s best offense, and LA will be looking to avoid an upset.