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49ers vs Buccaneers Predictions
Liam Isola

49ers vs Buccaneers Predictions, Picks & Odds: NFL Week 6 - Oct 12

Our NFL expert offers his 49ers vs Buccaneers predictions, picks, and odds for this Week 6 game between divisional leaders at 4:25pm ET (10/12).

The San Francisco 49ers and Tampa Bay Buccaneers will both look to improve to 5-1 when they meet on Sunday in Tampa. With the Bucs scoring and allowing a lot of points, over 47.5 points (-110) could be a popular pick tonight.

49ers vs Buccaneers Predictions - 4:25pm EDT - 10/12

  • Emeka Egbuka Anytime TD Scorer @ +135 with bet365
  • Mac Jones Over 250.5 Passing Yards @ -110 with bet365
  • Over 47.5 Points @ -110 with bet365

All odds are courtesy of bet365, correct at the time of publishing, and subject to change.

49ers vs Buccaneers Odds

  • Spread: Buccaneers -3 (-110)
  • Moneyline: 49ers (+135), Buccaneers (-160)
  • Total: O/U 47.5 (-110)

49ers vs Buccaneers Picks

Easy Money on Egbuka? - Emeka Egbuka Anytime TD Scorer (+135)

As long as Mike Evans is out injured, Emeka Egbuka should continue to be Bucs QB Baker Mayfield’s go-to guy. We successfully picked Egbuka to score last week, and we’re running it back today against a banged-up 49ers team.

The rookie had the best game of his short career last Sunday in the 38-35 win over the Seahawks. He caught his fifth touchdown pass of the season and managed seven receptions on seven targets for a whopping 163 receiving yards.

Mayfield is averaging two TD passes per game this season, while he’s had license to let it fly, especially over the last couple of weeks. The Bucs QB has thrown 73 passes in his last two games. He should continue to build his connection with Egbuka today.

So, one of today’s best bets is Egbuka to score, at +135 odds.

  • 49ers vs Buccaneers Prediction 1: Emeka Egbuka Anytime TD Scorer @ +135 with bet365

Mac Making Waves - Mac Jones Over 250.5 Passing Yards (-110)

It certainly looks like 49ers backup QB Mac Jones will start for a fourth time this season with starter Brock Purdy (turf toe) still not back in practice. Jones has been up to the task when he’s been called upon this season.

Last week, Jones threw for 342 yards and two TDs in a 26-23 overtime win over the Rams. His passing yard total for today is O/U 250.5 (-110), but he’s gone above that figure in each of his three starts this season.

Plus, the Bucs' secondary is nothing to write home about. They gave up 341 passing yards last week and only rank 21st in the league in opponent yards per passing attempt (6.8). I’d go with Jones to have another big day and throw for more than 250 yards.

  • 49ers vs Buccaneers Prediction 2: Mac Jones Over 250.5 Passing Yards @ -110 with bet365

Plenty of Points at the Pirate Ship - Over 47.5 Points (-110)

In Week 5, the Buccaneers put up 38 points against a Seattle Seahawks team that previously held opponents to 16.8 points per game. While the Bucs’ run game didn’t really get going, Baker Mayfield completed 29 of 33 passes for a season-high 379 yards.

Mayfield has been scary good this season, and can carry the Bucs’ offense again today. On the other side of the ball, Tampa hasn’t been great, as the Bucs have allowed 30+ points in back-to-back games.

The 49ers are averaging 22.6 points in Mac Jones’ three starts this season and should be able to find some success against Tampa’s defense. Expect both teams to air it out frequently today and bet on over 47.5 points (-110).

  • 49ers vs Buccaneers Prediction 3: Over 47.5 Points @ -110 with bet365

49ers vs Buccaneers Start Time

  • Start Time: 4:25pm EDT
  • Location: Raymond James Stadium
  • Address: 4201 N Dale Mabry Hwy, Tampa, FL 33607
  • TV & Streaming: CBS, Paramount+, Fubo, NFL+

The San Francisco 49ers (4-1) are on a four-game winning streak against the Tampa Bay Buccaneers (4-1). That may be all the motivation often aggrieved Bucs QB Baker Mayfield needs to have another big day.