Andy Robertson and Daniel Sturridge, both absent at the Rhein-Neckar-Arena, earn a place on the bench with Marko Grujic and Divock Origi dropping out.
If the England striker is substituted on, it will be his first appearance for Liverpool in the Champions League.
The Reds have never been eliminated from Europe after winning the first leg away from home. They have returned to Anfield for the reverse fixture with an advantage on 33 previous occasions.
Liverpool starting XI: Mignolet, Alexander-Arnold, Matip, Lovren, Moreno, Henderson, Can, Wijnaldum, Mane, Salah, Firmino
Substitutes: Karius, Klavan, Gomez, Milner, Robertson, Solanke, Sturridge
Hoffenheim starting XI: Baumann, Kaderabek, Nordtvelt, Demirbay, Wagner, Zuber, Hubner, Vogt, Kramaric, Gnabry, Geiger.
Substitutes: Kobel, Bicakcic, Rupp, Polanski, Toljan, Uth, Szalai.