Paulo Fonseca's side continue to play their home games in Kharkiv but haven't played a competitive match since their 1-1 draw with Lyon in mid-December. Despite that, 888Sport make the hosts 6/5 (2.20) favourites to establish a first leg lead.
The visitors won every group game they played this season, topping the table by a massive nine points and at 9/4 (3.25) they may appeal given it's been three months since Shakhtar's last competitive match. Adi Hutter has seen his side draw their previous three outings and another stalemate is priced at 12/5 (3.40) here.
While the German side have been an impressive force in this competition it's the prospect of goals that looks the most attractive punting prospect.
Frankfurt saw 22 goals in their six group games, scoring 17 of them. That trend of high-scoring games is also reflected in their Bundesliga form on the road this term. Seven of their 11 domestic matches away from home went over 2.5 goals and five of those saw four or more goals scored.
At 9/10 (1.90) with 888Sport, backing at least three goals to be scored in this game looks a solid option.
Shakhtar saw this selection land in five of their six Champions League group games and boast plenty of firepower with Brazilian trio Junior Moraes, Maycon and Taison in the final third.
While there may be some rust as far as the hosts are concerned, their strong home record should ensure they’re able to contribute to what looks to be an entertaining game in prospect. The 9/10 (1.90) about over 2.5 goals certainly makes plenty of appeal for this Europa League clash.