The Madrid Derby has been played in various different scenarios over the last few years, with these sides meeting in Champions League finals, semi-finals and quarter-finals and in the showpiece of the Copa Del Rey.
La Liga meetings between them have often proved vital to their end of season aspirations, although Sunday's clash will have mainly pride riding on it as the title is seemingly heading to Barcelona.
Nevertheless, both sides will want to entertain their fans and build confidence for the what remains of the campaign as they look to finish as high as possible in the league.
Ronaldo and Griezmann to battle
In bet365's goalscorer market, it is Cristiano Ronaldo who leads the way, with the Portuguese priced at 8/11 (1.72) to score at anytime and at 13/5 (3.60) to score first.
Madrid's star forward made headlines in midweek with his stunning bicycle kick against Juventus and his scoring form since the turn of the year has been extraordinary with 23 goals in his last 12 matches.
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Zinedine Zidane may be able to play his star men for 90 minutes after a 3-0 win in Turin ended their Champions League quarter-final clash as a contest, but Diego Simeone does not have that luxury.
Atleti beat Sporting CP 2-0 on Thursday night but have work to do int he second leg, meaning Antoine Griezmann could see limited playing time.
With that in mind, the 7/1 (8.00) on the Frenchman to open the scoring may appeal as he looks to make his mark early.
Bale with a point to prove
Gareth Bale has found himself on the edge of the first team again, with the Welshman scoring twice in Las Palmas last week in La Liga only to be an unused substitute in Turin.
The winger is likely to start on Sunday and is offered at a solid 11/10 (2.10) to score at anytime, with the former Spurs wideman having netted 11 league goals from 15 starts this term.
Value elsewhere
Atleti's second top scorer this season in La Liga is Angel Correa, with the Argentine priced at 7/2 (4.50) to add to his tally of seven goals.
Meanwhile, Saul Niguez often pops up with big goals from midfield and is available at 11/2 (6.50) to score at anytime.
Prices correct at the time of writing. Please gamble responsibly.
Gareth Bale to score at anytime at 11/10 (2.10) with bet365 for a 1.5pt stake
