Real Madrid have broken a Spanish scoring record by netting in their last 45 consecutive games in all competitions, a record for a Liga team.
Alvaro Morata thought he had opened the scoring, finding the back of the net after just 30 seconds, however his effort was ruled out for offside.
However, Isco made no mistake, firing home on eight minutes after a good ball from Mateo Kovacic.
Madrid did not have it all their own way, Tana grabbing one back for Las Palmas just two minutes later.
The goal means Madrid are now on the longest scoring streak ever by a La Liga side, beating the previous record held by Barcelona at 44 games.
45 - Real Madrid have scored in their last 45 games in all competitions, the best run of a La Liga side ever. Inmaculate. pic.twitter.com/XYiRhKmOYm— OptaJose (@OptaJose) March 1, 2017