Alexis Sanchez starts for Manchester United against former club Arsenal for the first time at Old Trafford on Sunday.
The Chile international moved to United in January as part of a swap deal, with Henrikh Mkhitaryan moving the other way, and will take to the field against the Gunners in Arsene Wenger's final visit to Old Trafford as Arsenal boss.
Arsenal, meanwhile, have made a host of changes, ahead of their clash Atletico Madrid in the second leg of the Europa League semi-final this week.
United make just one change to the XI which beat Tottenham Hotspur in last week's FA Cup semi-final, with Victor Lindelof stepping in to replace the injured Phil Jones at centre-back.
That means there is again no start for either Anthony Martial nor Marcus Rashford in the forward line as Jose Mourinho sticks with Jesse Lingard, Romelu Lukaku and Sanchez in a three-man attack.
Mkhitaryan returns for Arsenal following a knee injury to make his first appearance at Old Trafford since his winter move.
Elsewhere there is an Arsenal debut for 20-year-old Greek defender Konstantinos Mavropanos while Reiss Nelson and Alex Iwobi also start as Wenger makes a total of eight changes from Thursday's 1-1 draw with Atletico.
Manchester United XI: De Gea; Valencia, Lindelof, Smalling, Young; Herrera, Matic, Pogba; Lingard, Lukaku, Alexis.
Subs: Pereira, Rojo, Fellaini, Mata, McTominay, Martial, Rashford
Arsenal XI: Ospina; Bellerin, Chambers, Mavropanos, Kolasinac; Xhaka, Maitland-Niles; Iwobi, Nelson, Mkhitaryan; Aubameyang.
Subs: Cech, Holding, Monreal, Osei-Tutu, Willock, Welbeck, Nketiah.