Marco Silva has been Hull City manager for less than a month, but Wednesday's clash will be the third occasion on which the Tigers have faced United under Silva's stewardship.
Jose Mourinho's men enjoyed a thrilling EFL Cup semi-final victory against the Tigers, winning 3-2 on aggregate despite a 2-1 reverse on Humberside when these two teams met just last week.
United will feel confident, though, that their fine home form will help them to victory on this occasion; indeed, the men from Manchester are unbeaten in 17 matches at Old Trafford, winning all but one of their last eight games on home turf; as such, United are 2/11 (1.18) favourites with Betfair Sportsbook to take maximum points from this match.
The same firm have a huge new customer offer ahead of this game, offering United at 5/1 (6.0) for anyone without an online account. Simply register using the link provided, back Mourinho's men at the usual price shown on site and if they win, the returns will be topped up to the enhanced value. Winnings paid in free bets. T&C's apply.
The Tigers have a terrible record on the road, losing each of their last nine away games, with the latest defeat coming in a 4-1 loss against Championship side Fulham in the FA Cup on Sunday afternoon.
Hull can be backed at a chunky 18/1 (19.0) with Betfair Sportsbook to buck the trend by claiming a famous victory from this fixture, while they are chalked up as a 13/2 (7.50) chance to take a point from this crucial clash.
United have kept a clean sheet in each of their last three victories at Old Trafford and the odds compilers offer 7/10 (1.70) that Mourinho's men win without conceding; that play is particularly attractive for Hull have been toothless on their travels, scoring just twice in their last nine games away from home.
Mourinho's team have scored more than two goals in five of their last eight wins at home and Betfair Sportsbook offer 10/11 (1.91) that the men from Manchester manage more than two goals, while the same firm go 13/10 (2.30) that United (-2) come out on top in the handicap market.
Each of Manchester United's four goals against Hull so far this season have come in the second half and Betfair Sportsbook go 10/11 (1.91) that most of the scoring comes after the break. Moreover, the Tigers' approach certainly seems to keep things tight early on before becoming more expansive in the second half, having scored 75 per cent of their league goals after the break this season.
That particular play would have landed in four of United's last five wins at Old Trafford and, at 10/11 (1.91), the selection is certainly worthy of support again ahead of Wednesday's clash.