Having seen Crawley thump their promotion rivals Mansfield Town 4-1 at the weekend, Wrexham came into Tuesday's encounter well aware that they would need to be at their very best to get a much-needed result, amid a pitched promotion battle.
And as a result, they absolutely raced out of the traps, earning a 2-0 lead by the 23rd minute, with two goals in two minutes.
First, Ryan Barnett rose in the area to meet a superb cross from Elliot Lee, sending a header into the back of the net.
And then Paul Mullin found the net, as he finished a clever cut-back from Andy Cannon to put Phil Parkinson's men firmly in control.
Lee could have added a third before half-time, but his effort hit the post after more good work from Cannon.
In the second half, Wrexham again scored twice, as Cannon tapped in a rebound, and Mullin capitalised on a defensive mistake to add his second and Wrexham's fourth.
Crawley added a late consolation, as Klaidi Lolos tapped in a cross from close-range, but it did nothing to alter a thumping defeat.