Wirtz linked well at times with Salah and Gakpo during the first half but was occasionally guilty of taking the wrong decision. However, the Germany international managed to get his first goal for Liverpool shortly before being replaced, after arriving right on cue to fire home a cutback from Salah that Jones unintentionally flicked right into his path.
Meanwhile, Wirtz's former Bayer Leverkusen team-mate, Frimpong, left Nyoni with a pretty straightforward finish thanks to a wonderful whipped cross.
As for Ekitike, he impressed with his work-rate and general movement but didn't get many clear sights of goal. However, he did go close with an ingenious back-heeled effort from an acute angle after reacting first to Conor Bradley's low cross.
In defence, Giorgio Mamardashvili once again started in goal due to the unavailability of Alisson, who returned to his native Brazil for personal reasons, and the Georgian impressed with his distribution, while he also made a good save from Dean David during the first half.
There was also a start for Milos Kerkez, who was caught out of position a few times but always provided a decent outlet down the left-hand side.