So impressive were their performances in the lead-up to Thomas Tuchel naming his first England squad earlier in March, that there were calls for both teenagers to be included in the group - which gained traction with a number of the Three Lions' attacking players out of form and the left-back position a serious problem in Luke Shaw's continued injury absence.
Ultimately it was 18-year-old Lewis-Skelly who was included in the senior squad, with Nwaneri instead called up to a talent-packed U21 squad alongside the likes of Adam Wharton, Liam Delap, Jamie Gittens and Jobe Bellingham.
Speaking after calling up the midfielder-turned-full-back, Tuchel said: "We were always impressed with Myles. Since he started, he quickly became a regular player for Arsenal, the second-best team in the country at the moment and quarter-finalists in the Champions League.
"I can understand if it feels like we fast-forwarded a career that was already fast-paced. I can assure you that the talks of the last days and weeks have had a kind of parental and protective vibe. To even feel like we should not nominate him to protect him a little bit and not skip the Under-21s.
"Is this even maybe our responsibility to not take him? But in the end with injuries, and the quality and maturity that he’s shown in the matches, we decided to take him."
Their paths may have briefly diverged, but if Nwaneri continues on his current course he will be a serious contender for England's 2026 World Cup squad in a year's time. Meanwhile, Lewis-Skelly has an early opportunity to make the left-back berth his own for years to come.
You need only glance at the U21 squad and the calibre of the under-25 players in the senior setup to understand that the national team's future is hugely exciting, and these two are primed to play a huge part in that.