The Nigerian international was asked for his prediction for the game and has also revealed which of his team-mates would be most suited to American football.
Speaking at the NFL UK Super Bowl LI party, Iwobi said: "100% Patriots. I just can’t see past their offense, Tom Brady is the man. I love an underdog but Patriots to win by 10.”
As for his club-mate most suited to playing in the game, he said: “It's got to be Francis Coquelin. Not because of his size, but because of his natural aggression and desire to win at all costs.”
Winks is in agreement with his Arsenal rival but gave Harry Kane his backing as a player who could success in the NFL.
“The Patriots have to win. I don’t know too much about Tom Brady but from what I’ve heard, he is a top player who can win the game for them," he added.
“I think Harry Kane would probably be a team-mate that could make it in the NFL. He has great technique when striking the ball so there’s no reason why he couldn’t be a top place kicker."
Spurs and Arsenal go into the weekend level of points, with Mauricio Pochetttino's men ahead on goal difference and Winks has explained why the team are on such a good run of form.
“Playing for Spurs is a dream come true every time I go out on the field," he explained.
“At the moment we have a very good team spirit, we just get on really well as a bunch of boys, we’ve just come back from a trip to Barcelona and we all respect each other.
“I always looked up to someone like Scott Parker when I was a youngster coming through, he was a top player, him and Luca Modric are both top players I really admire.”
Alex Iwobi, Harry Winks, Ndamukong Suh and Menelik Watson were attending the NFL Super Bowl LI party ahead of this Sunday’s Super Bowl, which will see the New England Patriots face the Atlanta Falcons in Houston this Sunday. You can catch all of the action from 11.20pm on BBC One or Sky Sports 1 from 10.00pm, with kick-off at 11.30pm.