Last weekend saw Granada suffer their fifth straight defeat which confirmed their return to the second division after a six-year stint in the Spanish top flight.
The surprise appointment of Tony Adams as caretaker coach last month has done little to invigorate the side, and Saturday afternoon could be the last game against one of the country's big clubs for some time.
Real Madrid visit the Estadio Nuevo Los Carmenes following a magnificent 3-0 midweek Champions League success over Atletico Madrid and Zinedine Zidane is likely to rest players ahead of the second leg of their semi-final on Wednesday.
The bad news for Granada is that Zidane's 'B Team', as it has been dubbed in Spain, has been in rampant form and whenever the manager has rung the changes, the side have responded brilliantly.
Real Madrid have won their last six away games in La Liga scoring 22 times in the process and their last game on the road saw them put six past Deportivo La Coruna, a ground where this season both Barcelona and Atletico Madrid failed to win.
The likes of Alvaro Morata, Marco Asensio, Mateo Kovacic and James Rodriguez are all likely to come into the side and Betfair price an away win at just 1/10 (1.10), with a victory for Granada offered at 28/1 (29.00) and the draw available at 9/1 (10.00).
Despite Cristiano Ronaldo being unlikely to feature at all for Real Madrid, Los Blancos have proven more than capable of getting among the goals without the Ballon d'Or holder, who did not feature in the goalfest at Deportivo, nor in the recent matches in Eibar or Leganes where Madrid scored four on both occasions.
Zidane's men are offered at 19/20 (1.95) to score over 3.5 goals and that looks like a tempting option. Barcelona had already managed to net four times in their visit to Granada last month, while Madrid put five past the Andalusians when they hosted them at the Bernabeu in January.
Another angle could be backing the visitors to win with a -3 handicap at 13/8 (2.62) which could offer some value, although Madrid's record of one clean sheet in 13 league games perhaps make that option less tempting.