Kylian Mbappe was the hero for the French league leaders in Dortmund, scoring twice and the teenage sensation could hold the key to victory for Jardim's team again on this occasion.
Radamel Falcao has enjoyed an upturn in fortunes this season after a couple of disappointing seasons in English football and the experienced Colombian will be determined to make his mark for Jardim's outfit.
Falcao has fired sIx goals in seven games in European competition this season and Betfair Sportsbook go 9/2 (5.50) that Falcao grabs the opening goal and 5/4 (2.25) that the former Chelsea and Manchester United striker finds the net at any time.
Portuguese midfielder Bernardo Silva has scored three goals in five Champions League matches on the road for Monaco thus far this term and the odds compilers offer 2/1 (3.0) that Silva strikes at any time in this tie and 15/2 (8.50) that the former Benfica star opens the scoring against the Germans.
Thomas Tuchel's charges trail after the first leg, but the Dortmund boss will have confidence that his team can turn the tie around, for the Bundesliga outfit have plenty of players who are capable of putting the ball in the net.
Pierre-Emerick Aubameyang is Dortmund's leading marksman; the Gabon international has notched 33 goals this term and Betfair Sportsbook go 10/11 (1.91) that the striker scores at any time.
Dortmund's Japan international, Shinji Kagawa, scored his side's second goal on home soil last week to leave the tie finely balanced and the midfielder's goal could well prove pivotal for Tuchel's men; Kagawa is available at 2/1 (3.0) to add to his tally in this tie against the Ligue 1 leaders.
Ousmane Dembele scored for Dortmund last week and the French teenage star could offer decent value at a chunky 13/2 (7.50) to strike first in Monaco, with 9/5 (2.80) that the 19-year-old makes his mark at any time.
Both sides boast an impressive array of attacking talent and the goals may well flow once again when these two teams lock horns in this crucial Champions League clash.