Esteghlal are currently fifth in the AFC Champions League table - having accumulated three points from their first two matches in the competition.
On the other hand, the three-time Caf Champions League winner's new club has collected eight points after seven games in the Persian Gulf Pro League so far.
Mosimane faced Al-Nassr in April as Abha's coach in the Saudi Pro League match and lost 8-0 with Ronaldo scoring a hat-trick.