Both the Soweto giants will be in the Democratic Republic of Congo this weekend.
Kaizer Chiefs will play AS Simba in the first leg of the second preliminary round of the CAF Confederation Cup in Lubumbashi, while Orlando Pirates will be up against St Eloi Lupopo in the same city a day later, but in the CAF Champions League.
Stellenbosch will be in Equatorial Guinea to play their hosts Agosto in Africa's second-tier competition.
The defending Premier Soccer League champions, Mamelodi Sundowns, will be in Nigeria to face Remo Stars.