Sundowns are gearing up for a match against a side that eliminated them last season in the semi-final, hoping for revenge. Cardoso masterminded a 2-0 aggregate win against the Premier Soccer League heavyweights.
This time around, it is Mokwana, who signed for Esperance in August last year, who could help end Sundowns' journey in the continental competition.
Before he left for Esperance, the forward had been heavily linked with Kaizer Chiefs. Although he snubbed the Soweto giants to join the Tunisian heavyweights, he is open to a future move to Naturena.
But for now, his focus is on the Champions League, where he hopes to inspire Esperance past the Tshwane giants and progress to the last four.
If he starts, this is a match in which Mokwana would want to shine and show Chiefs what they could have missed by not signing him.