The Seagulls are edging towards Premier League safety but suffered a setback when they were beaten by Christian Eriksen's sublime late goal for Tottenham in midweek. Nevertheless, the point procured at Wolves last weekend could yet prove pivotal.
Rafa Benitez's men will make the long journey south in confident mood. Newcastle are already assured of a Premier League place next season and have won both of their last two Premier League matches.
Brighton can be backed at 5/4 (2.25) with SportPesa to secure a vital victory against the Magpies this weekend.
Glenn Murray and Solly March were named as substitutes for Tuesday's trip to Tottenham. Both men could return for the Seagulls this weekend. There could also be an immediate recall for Anthony Knockaert, who returns from a three-match ban.
Miguel Almiron will join Sean Longstaff and Florian Lejeune on the sidelines for the remainder of the season for Newcastle. Fabian Schar is also expected to miss out this weekend.
Goals at a premium
Brighton have now failed to score in seven successive matches in all competitions and five of those fixtures produced fewer than three goals. Furthermore, there have been fewer than three goals scored in five of Newcastle's last six away matches.
Despite securing their Premier League place, Newcastle remain unconvincing on their travels. Benitez's team have won just one of their last 10 away matches inside 90 minutes and only three Premier League matches on the road all season.
The likely return of Murray, March and Knockaert will surely boost Brighton. Hughton's men know that victory here will go a long way to ensuring a Premier League place for the Seagulls next season.
Brighton have bagged 22 of their 34 league points on their own patch this term and so it is SportPesa's 5/4 (2.25) quote for a home win, therefore, could represent real value ahead of this weekend's clash at Amex Stadium.