It's now been eight games in all competitions since Salah found the back of the net for Liverpool - his longest run since a 10 match streak with Roma at the tail end of 2015.
While the lack of goals has worried some, Jurgen Klopp has backed Salah's form throughout a dry spell which does look destined to end on Saturday morning (AEST).
The pacey winger has scored in all three of his past matches against the Saints, boasting four goals in total as he becomes a real thorn in Southampton's side.
With Salah set to fire, recent history suggests Liverpool are in pole position to claim a vital three points which would temporarily take them back to the Premier League summit.
The Reds are looking to claim a fourth straight league win against Southampton - something they've never achieved in their history.
The Saints meanwhile are winless in their past five league matches against Liverpool, with Jurgen Klopp's side also discovering new-found defensive resilience on the road this season.
Liverpool has conceded just nine goals across 16 away Premier League game this campaign, a feat matched only by Manchester City.
Though history is against Southampton, Ralph Hasenhuttl's side has finally found some form and are looking to claim a third consecutive win for the first time since May 2016.
Jurgen Klopp's men are ticking along even better, however, winning their past four matches in all competitions and losing just one match in 2019 to date.
As Liverpool desperately look to avoid any Premier League slip-ups, the Reds will be hoping Salah can once again step up in front of goal as he returns to haunts the Saints.