Sitting third in the Premier League, Tottenham are desperate for three points to prevent Manchester City from slipping further away at the top of the table.
Mauricio Pochettino's side have won all but one of their last six games in the league and come up against a side coming off the back of a defeat to Chelsea before the international week.
Sitting four points behind their rivals, Arsenal cannot afford to slip up at home or else lose further ground on the title challenge and Champions League places.
But which players available for selection from each side would make a combined XI judged on their form so far this season? Goal takes a shot at picking the team...
HUGO LLORIS (Tottenham) - Hailed as one of the best in the world by Mauricio Pochettino last month, Hugo Lloris has been solid at the back for one of the strongest defences in the Premier League. The Frenchman has kept five clean sheets in 10 top flight games and is always a pivotal figure in big games for Spurs.
DAVINSON SANCHEZ (Tottenham) - The Colombian has slotted seamlessly into the starting XI since joining the English side from Ajax. Fast and always on alert, the 21-year-old is a defensive rock who can add to the attack with charges forward and his aerial presence.
JAN VERTONGHEN (Tottenham) - The former Ajax star has played every minute of Premier League football this season and is integral to the success of their defence as a consistently solid performer and leader. As his team’s top passer, the 30-year-old is vital in building their attacks, too.
LAURENT KOSCIELNY (Arsenal) - While Arsenal have been leaking goals, 32-year-old Koscielny has still shown his class in tough situations through his interceptions, aerial ability and passing. Wenger’s key man in the defence, he will be vital for Saturday’s derby.
HECTOR BELLERIN (Arsenal) - An ever-present on the right flank for the Gunners, Bellerin adds to the attack with his pace and crosses, while the 22-year-old’s defensive work has helped cover the back three.
ERIC DIER (Tottenham) - Dier’s excellent displays for Spurs saw him handed the England captaincy for last week’s games against Germany and Brazil and at 23, he is a candidate to keep it for the long-term. The defensive midfielder has been pivotal in the centre of the field, but he has already impressed at right full-back this season.
DELE ALLI (Tottenham) - The 21-year-old seems to be constantly improving and remains deadly in front of goal with seven from 13 in all competitions. A central figure for Pochettino's promising side, it is obvious why the the midfielder is regarded as one of his country's top young talents.
CHRISTIAN ERIKSEN (Tottenham) - “We're seeing the best Christian Eriksen we've ever seen at the moment,” Eric Dier said this week and the attacking midfielder’s hat-trick for Denmark against Ireland on Tuesday was a testament to that. The creative No.10 has been sublime for club and country in recent years and is excelling this term with goals and assists as well as carving out chances.
SEAD KOLASINAC (Arsenal) - Bosnia-Herzegovina international Kolasinac has proved an incredible signing for Arsenal after joining for Schalke for free. His pace and strength make him a great asset on the left side and already has three goals and three assists in 12 games across all competitions.
ALEXANDRE LACAZETTE (Arsenal) - The French striker has been an effective signing for the Gunners already. With six goals from 11 league games, he has helped cover for wantaway star Alexis Sanchez and provides their attack with some much-needed firepower.
HARRY KANE (Tottenham) - The England superstar remains in incredible form with 13 goals in 14 games in all competition for the north London side. With eight of the 20 his side have scored in the league this term, if he keeps up his current form it may not be long before the Spurs are labelled the “Harry Kane team” once again.